![]() ambulatory settings including primary, specialty care and inpatient settings), or sometimes Study Design (such as a randomized controlled trial). the time it takes to demonstrate an outcome OR the period in which patients are observed. T refers to Timing and S refers to Setting or Study Design. In addition to the standard PICO components, the broader PICOTS framework is extremely useful and important for defining key clinical questions and assessing whether a given study is applicable or not. O: The clinical outcome(s) of interest, including a time horizon, if relevant. I: The main intervention, defined very broadly, including an exposure, a diagnostic test, a prognostic factor, a treatment, a patient perception and so forth.Ĭ: A comparison intervention or exposure (also defined very broadly), if relevant. P: The patient situation, population, or problem of interest. When well built, clinical questions usually have four components: Publications Co-authored or Contributed to by Library Staff.The Making Cancer History® Voices Oral History Project.
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